IONS
insider transactionsIONIS PHARMACEUTICALS INC — buys & sells by directors, officers and 10% owners A shareholder owning more than 10% of the company. Must report trades, but usually a weaker signal than an officer or director. (SEC Form 4).
Net shares · 90d
-215.4K
0 buy · 215.4K sell
Net value · 90d
-$16.1M
$0 in · $16.1M out
Sentiment · 90d
Net selling
0% buying · 100% selling
Open-market trades · 90d
19
0 buy · 215.4K sell
Net buy / sell volume
Not enough data to chart yet.
Tap or hover the chart for daily net volume. Green = net buying, red = net selling.
All transactions
-
Exercise·M
Director · 10b5-1
$0
8.0K sh
Own New
-
Sell·S
Director · 10b5-1
$587.9K
8.0K sh · $73.49
Own -5%
-
Exercise·M
Director · 10b5-1
$195.4K
8.0K sh · $24.42
Own +5%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$0
21.0K sh
Own New
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$0
8.0K sh
Own +61%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$0
19.9K sh
Own New
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$0
12.0K sh
Own New
-
Sell·S
EVP, Chief Development Officer · 10b5-1
$1.5M
19.8K sh · $74.05
Own -47%
-
Sell·S
EVP, Chief Development Officer · 10b5-1
$3.0M
41.0K sh · $73.09
Own -49%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$1.1M
19.9K sh · $56.78
Own +31%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$391.2K
12.0K sh · $32.60
Own +23%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$1.3M
21.0K sh · $60.89
Own +69%
-
Exercise·M
EVP, Chief Development Officer · 10b5-1
$484.1K
8.0K sh · $60.89
Own +35%
-
Grant·A
Director
$0
10.8K sh
Own New
-
Grant·A
Director
$0
10.8K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
8.0K sh
Own New
-
Sell·S
Director · 10b5-1
$605.4K
8.0K sh · $75.67
Own -5%
-
Exercise·M
Director · 10b5-1
$195.4K
8.0K sh · $24.42
Own +5%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$0
3.2K sh
Own +10%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$253.3K
3.2K sh · $78.68
Own -1%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$105.0K
3.2K sh · $32.60
Own +1%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$0
1.3K sh
Own +4%
-
Sell·S
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$102.7K
1.3K sh · $78.01
Own -1%
-
Exercise·M
Brett P Monia KEY
Chief Executive Officer · 10b5-1
$42.9K
1.3K sh · $32.60
Own +1%
-
Exercise·M
Director · 10b5-1
$0
16.0K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
10.3K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
12.0K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
11.0K sh
Own New
-
Sell·S
Director · 10b5-1
$1.3M
17.8K sh · $75.58
Own -33%
-
Sell·S
Director · 10b5-1
$4.5M
59.5K sh · $74.90
Own -52%
-
Exercise·M
Director · 10b5-1
$1.0M
16.0K sh · $64.80
Own +16%
-
Exercise·M
Director · 10b5-1
$722.4K
12.0K sh · $60.20
Own +14%
-
Exercise·M
Director · 10b5-1
$686.1K
16.0K sh · $42.88
Own +23%
-
Exercise·M
Director · 10b5-1
$424.0K
10.3K sh · $41.08
Own +17%
-
Exercise·M
Director · 10b5-1
$480.6K
12.0K sh · $40.05
Own +25%
-
Exercise·M
Director · 10b5-1
$417.4K
11.0K sh · $38.06
Own +30%
-
Exercise·M
Director · 10b5-1
$0
10.1K sh
Own New
-
Sell·S
Director · 10b5-1
$106.5K
1.4K sh · $74.45
Own -11%
-
Sell·S
Director · 10b5-1
$636.7K
8.7K sh · $73.35
Own -41%
-
Exercise·M
Director · 10b5-1
$476.3K
10.1K sh · $47.11
Own +92%
-
Sell·S
EVP, Chief Business Officer · 10b5-1
$116.7K
1.6K sh · $71.79
Own -3%
-
Sell·S
EVP, Chf GL Pdt Str Ofcr
$368.5K
4.9K sh · $75.17
Own -17%
-
Sell·S
EVP, Corp and Development Ops
$73.0K
973 sh · $75.04
Own -1%
-
Sell·S
EVP, Chief Business Officer
$419.0K
5.6K sh · $74.56
Own -11%
-
Sell·S
Director · 10b5-1
$41.1K
534 sh · $76.97
Own -1%
-
Sell·S
Director · 10b5-1
$340.3K
4.5K sh · $76.19
Own -8%
-
Exercise·M
EVP, Chf GL Pdt Str Ofcr
$0
12.2K sh
Own +20%
-
Exercise·M
EVP, Chf GL Pdt Str Ofcr
$0
12.2K sh
Own +75%
-
Exercise·M
EVP, Corp and Development Ops
$0
1.9K sh
Own +4%
-
Exercise·M
EVP, Corp and Development Ops
$0
1.9K sh
Own +3%
-
Exercise·M
EVP, Chief Business Officer
$0
10.8K sh
Own +29%
-
Exercise·M
EVP, Chief Business Officer
$0
10.8K sh
Own +26%
-
Other·D
Director
—
5.5K sh
Own -100%
-
Other·D
Director
—
4.5K sh
Own -100%
-
Other·D
Director
—
4.2K sh
Own -100%
-
Other·D
Director
—
5.3K sh
Own -100%
-
Other·D
Director
—
5.1K sh
Own -100%
-
Other·D
Director
—
7.3K sh
Own -100%
-
Other·D
Director
—
6.5K sh
Own -100%
-
Other·D
Director
—
2.0K sh
Own -100%
-
Other·D
Director
—
16.1K sh
Own -100%
-
Sell·S
EVP, Chief Human Resources Ofc · 10b5-1
$458.6K
6.2K sh · $74.05
Own -27%
-
Exercise·M
Director · 10b5-1
$0
10.3K sh
Own New
-
Exercise·M
Director · 10b5-1
$0
12.0K sh
Own New
-
Sell·S
Director · 10b5-1
$168.3K
2.2K sh · $75.95
Own -17%
-
Sell·S
Director · 10b5-1
$1.5M
20.1K sh · $75.50
Own -60%
-
Exercise·M
Director · 10b5-1
$424.0K
10.3K sh · $41.08
Own +45%
-
Exercise·M
Director · 10b5-1
$456.7K
12.0K sh · $38.06
Own +109%
| Date▾ | Insider | Type | Shares | Value |
|---|---|---|---|---|
| Jun 15, 2026 | BERTHELSEN SPENCER R 10b5-1 | Exercise M | 8.0K | $0 |
| Jun 15, 2026 | BERTHELSEN SPENCER R 10b5-1 | Sell S | 8.0K | $587.9K |
| Jun 15, 2026 | BERTHELSEN SPENCER R 10b5-1 | Exercise M | 8.0K | $195.4K |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 21.0K | $0 |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 8.0K | $0 |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 19.9K | $0 |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 12.0K | $0 |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Sell S | 19.8K | $1.5M |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Sell S | 41.0K | $3.0M |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 19.9K | $1.1M |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 12.0K | $391.2K |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 21.0K | $1.3M |
| Jun 12, 2026 | Holly B. Kordasiewicz 10b5-1 | Exercise M | 8.0K | $484.1K |
| Jun 4, 2026 | Peter N Reikes | Grant A | 10.8K | $0 |
| Jun 4, 2026 | Ludwig Hantson | Grant A | 10.8K | $0 |
| Jun 1, 2026 | BERTHELSEN SPENCER R 10b5-1 | Exercise M | 8.0K | $0 |
| Jun 1, 2026 | BERTHELSEN SPENCER R 10b5-1 | Sell S | 8.0K | $605.4K |
| Jun 1, 2026 | BERTHELSEN SPENCER R 10b5-1 | Exercise M | 8.0K | $195.4K |
| May 14, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 3.2K | $0 |
| May 14, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 3.2K | $253.3K |
| May 14, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 3.2K | $105.0K |
| May 13, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 1.3K | $0 |
| May 13, 2026 | Brett P Monia KEY 10b5-1 | Sell S | 1.3K | $102.7K |
| May 13, 2026 | Brett P Monia KEY 10b5-1 | Exercise M | 1.3K | $42.9K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 16.0K | $0 |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 10.3K | $0 |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 12.0K | $0 |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 11.0K | $0 |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Sell S | 17.8K | $1.3M |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Sell S | 59.5K | $4.5M |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 16.0K | $1.0M |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 12.0K | $722.4K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 16.0K | $686.1K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 10.3K | $424.0K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 12.0K | $480.6K |
| May 4, 2026 | Joseph Loscalzo 10b5-1 | Exercise M | 11.0K | $417.4K |
| May 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 10.1K | $0 |
| May 1, 2026 | Joseph Klein III 10b5-1 | Sell S | 1.4K | $106.5K |
| May 1, 2026 | Joseph Klein III 10b5-1 | Sell S | 8.7K | $636.7K |
| May 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 10.1K | $476.3K |
| Apr 28, 2026 | Joseph Baroldi 10b5-1 | Sell S | 1.6K | $116.7K |
| Apr 16, 2026 | Kyle Jenne | Sell S | 4.9K | $368.5K |
| Apr 16, 2026 | Brian Birchler | Sell S | 973 | $73.0K |
| Apr 16, 2026 | Joseph Baroldi | Sell S | 5.6K | $419.0K |
| Apr 15, 2026 | Lynne B Parshall 10b5-1 | Sell S | 534 | $41.1K |
| Apr 15, 2026 | Lynne B Parshall 10b5-1 | Sell S | 4.5K | $340.3K |
| Apr 15, 2026 | Kyle Jenne | Exercise M | 12.2K | $0 |
| Apr 15, 2026 | Kyle Jenne | Exercise M | 12.2K | $0 |
| Apr 15, 2026 | Brian Birchler | Exercise M | 1.9K | $0 |
| Apr 15, 2026 | Brian Birchler | Exercise M | 1.9K | $0 |
| Apr 15, 2026 | Joseph Baroldi | Exercise M | 10.8K | $0 |
| Apr 15, 2026 | Joseph Baroldi | Exercise M | 10.8K | $0 |
| Apr 7, 2026 | Ludwig Hantson | Other D | 5.5K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 4.5K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 4.2K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 5.3K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 5.1K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 7.3K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 6.5K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 2.0K | — |
| Apr 7, 2026 | Ludwig Hantson | Other D | 16.1K | — |
| Apr 2, 2026 | Shannon L. Devers 10b5-1 | Sell S | 6.2K | $458.6K |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 10.3K | $0 |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 12.0K | $0 |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Sell S | 2.2K | $168.3K |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Sell S | 20.1K | $1.5M |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 10.3K | $424.0K |
| Apr 1, 2026 | Joseph Klein III 10b5-1 | Exercise M | 12.0K | $456.7K |
About IONS insider trading
This page tracks insider transactions for IONIS PHARMACEUTICALS INC (IONS) reported to the U.S. Securities and Exchange Commission on Form 4. Corporate insiders — directors, executive officers and beneficial owners of more than 10% of the stock — must disclose their trades within two business days. Open-market purchases (code P) and sales (code S) made at the insider's discretion are the most-watched opportunistic signals, while awards (A), option exercises (M) and tax-withholding (F) reflect compensation rather than conviction. Trades marked 10b5-1 were made under a pre-arranged plan and are considered routine. A cluster buy — several insiders buying within a short window — is historically a stronger bullish indicator than any single trade.