PTGX
insider transactionsProtagonist Therapeutics, Inc — buys & sells by directors, officers and 10% owners A shareholder owning more than 10% of the company. Must report trades, but usually a weaker signal than an officer or director. (SEC Form 4).
Net shares · 365d
-555.5K
0 buy · 555.5K sell
Net value · 365d
-$52.5M
$0 in · $52.5M out
Sentiment · 365d
Net selling
0% buying · 100% selling
Open-market trades · 365d
28
0 buy · 555.5K sell
Net buy / sell volume
Not enough data to chart yet.
Tap or hover the chart for daily net volume. Green = net buying, red = net selling.
All transactions
-
Exercise·M
Director · 10b5-1
$0
6.0K sh
Own +200%
-
Exercise·M
Director · 10b5-1
$0
3.0K sh
Own New
-
Sell·S
Director · 10b5-1
$969.1K
9.0K sh · $107.68
Own -53%
-
Exercise·M
Director · 10b5-1
$99.2K
6.0K sh · $16.54
Own +55%
-
Exercise·M
Director · 10b5-1
$35.4K
3.0K sh · $11.80
Own +38%
-
Exercise·M
Director · 10b5-1
$0
9.0K sh
Own New
-
Sell·S
Director · 10b5-1
$896.8K
9.0K sh · $99.64
Own -53%
-
Exercise·M
Director · 10b5-1
$106.2K
9.0K sh · $11.80
Own +115%
-
Exercise·M
President and CEO
$0
75.0K sh
Own +50%
-
Sell·S
President and CEO
$7.5M
75.0K sh · $100.12
Own -13%
-
Exercise·M
President and CEO
$1.6M
75.0K sh · $21.58
Own +14%
-
Exercise·M
President and CEO · 10b5-1
$0
75.0K sh
Own +50%
-
Sell·S
President and CEO · 10b5-1
$7.5M
75.0K sh · $100.12
Own -13%
-
Exercise·M
President and CEO · 10b5-1
$1.6M
75.0K sh · $21.58
Own +14%
-
Sell·S
Director
$513.0K
5.1K sh · $100.00
Own -29%
-
Sell·S
Director
$600.0K
6.0K sh · $100.00
Own -100%
-
Exercise·M
Director
$0
12.0K sh
Own New
-
Exercise·M
Director
$0
24.0K sh
Own New
-
Sell·S
Director
$1.2M
12.0K sh · $100.07
Own -67%
-
Sell·S
Director
$3.6M
36.0K sh · $100.14
Own -56%
-
Exercise·M
Director
$83.8K
12.0K sh · $6.98
Own +38%
-
Exercise·M
Director
$154.8K
24.0K sh · $6.45
Own +307%
-
Other·G
President and CEO
$0
1.5K sh
Own -0%
-
Sell·S
Asif Ali KEY
Chief Financial Officer
$184.6K
1.8K sh · $105.47
Own -3%
-
Exercise·M
Director
$0
24.0K sh
Own New
-
Sell·S
Director
$2.5M
24.0K sh · $105.00
Own -28%
-
Exercise·M
Director
$309.1K
24.0K sh · $12.88
Own +39%
-
Exercise·M
Chief Medical Officer
$0
15.0K sh
Own +42%
-
Sell·S
Chief Medical Officer
$1.6M
15.0K sh · $104.79
Own -15%
-
Exercise·M
Chief Medical Officer
$120.6K
15.0K sh · $8.04
Own +18%
-
Exercise·M
Asif Ali KEY
Chief Financial Officer
$0
5.3K sh
Own +66%
-
Exercise·M
Asif Ali KEY
Chief Financial Officer
$0
19.5K sh
Own +165%
-
Sell·S
Asif Ali KEY
Chief Financial Officer
$2.6M
24.8K sh · $104.24
Own -29%
-
Exercise·M
Asif Ali KEY
Chief Financial Officer
$64.1K
5.3K sh · $12.17
Own +7%
-
Exercise·M
Asif Ali KEY
Chief Financial Officer
$374.2K
19.5K sh · $19.19
Own +32%
-
Exercise·M
President and CEO
$0
54.6K sh
Own New
-
Sell·S
President and CEO
$5.5M
54.6K sh · $101.00
Own -9%
-
Exercise·M
President and CEO
$468.8K
54.6K sh · $8.58
Own +10%
-
Exercise·M
President and CEO
$0
59 sh
Own +0%
-
Sell·S
President and CEO
$6.0K
59 sh · $101.00
Own -0%
-
Exercise·M
President and CEO
$506
59 sh · $8.58
Own +0%
-
Other·G
President and CEO
$0
50.0K sh
Own -9%
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
96.7K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
47.7K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
60.0K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
100.0K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
176.7K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
211.5K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
181.2K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
543.8K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
638.0K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
—
693.8K sh
Own New
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
96.7K sh
Own -100%
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
47.7K sh
Own -100%
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
60.0K sh
Own -100%
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
100.0K sh
Own -100%
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
176.7K sh
Own -100%
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
211.5K sh
Own -100%
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
181.2K sh
Own -100%
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
543.8K sh
Own -100%
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
638.0K sh
Own -100%
-
Other·D
Bryan Giraudo KEY
COO/CFO
—
693.8K sh
Own -100%
-
Exercise·M
Director
$0
18.0K sh
Own New
-
Sell·S
Director
$1.5M
18.0K sh · $82.42
Own -70%
-
Exercise·M
Director
$195.1K
18.0K sh · $10.84
Own +230%
-
Exercise·M
Director
$0
20.0K sh
Own New
-
Sell·S
Director
$1.7M
20.0K sh · $83.68
Own -72%
-
Exercise·M
Director
$166.2K
20.0K sh · $8.31
Own +256%
-
Exercise·M
President and CEO
$0
4.1K sh
Own +1%
-
Sell·S
President and CEO
$338.4K
4.1K sh · $83.19
Own -1%
-
Exercise·M
President and CEO
$87.8K
4.1K sh · $21.58
Own +1%
-
Exercise·M
Chief Medical Officer
$0
5.0K sh
Own +8%
-
Sell·S
Chief Medical Officer
$410.0K
5.0K sh · $82.00
Own -6%
-
Exercise·M
Chief Medical Officer
$40.2K
5.0K sh · $8.04
Own +6%
-
Exercise·M
Asif Ali KEY
Chief Financial Officer
$0
12.0K sh
Own +183%
-
Exercise·M
Asif Ali KEY
Chief Financial Officer
$0
16.0K sh
Own +46%
-
Sell·S
Asif Ali KEY
Chief Financial Officer
$1.5M
18.2K sh · $83.14
Own -23%
-
Sell·S
Asif Ali KEY
Chief Financial Officer
$2.3M
28.0K sh · $83.13
Own -26%
-
Exercise·M
Asif Ali KEY
Chief Financial Officer
$146.0K
12.0K sh · $12.17
Own +13%
-
Exercise·M
Asif Ali KEY
Chief Financial Officer
$307.0K
16.0K sh · $19.19
Own +20%
-
Exercise·M
President and CEO
$0
14.2K sh
Own +5%
-
Exercise·M
President and CEO
$0
10.7K sh
Own New
-
Sell·S
President and CEO
$1.2M
14.2K sh · $84.05
Own -2%
-
Exercise·M
President and CEO
$306.5K
14.2K sh · $21.58
Own +2%
-
Sell·S
President and CEO
$897.5K
10.7K sh · $84.00
Own -2%
-
Exercise·M
President and CEO
$45.0K
10.7K sh · $4.21
Own +2%
-
Exercise·M
Chief Medical Officer
$0
5.0K sh
Own +8%
-
Sell·S
Chief Medical Officer
$411.4K
5.0K sh · $82.28
Own -6%
-
Exercise·M
Chief Medical Officer
$40.2K
5.0K sh · $8.04
Own +6%
-
Exercise·M
President and CEO
$0
19.3K sh
Own New
-
Sell·S
President and CEO
$1.6M
19.3K sh · $84.59
Own -3%
-
Exercise·M
President and CEO
$81.3K
19.3K sh · $4.21
Own +3%
-
Other·G
President and CEO
$0
6.0K sh
Own -1%
-
Sell·S
Chief Medical Officer
$1.1M
13.2K sh · $82.42
Own -14%
-
Sell·S
President and CEO
$2.8M
34.4K sh · $82.48
Own -6%
-
Sell·S
Chief Medical Officer
$784.7K
9.5K sh · $82.48
Own -9%
-
Sell·S
Asif Ali KEY
Chief Financial Officer
$708.3K
8.6K sh · $82.48
Own -10%
-
Exercise·M
Director
$0
14.3K sh
Own New
-
Exercise·M
Director
$60.2K
14.3K sh · $4.21
Own +31%
-
Grant·A
Bryan Giraudo KEY
COO/CFO
$0
693.8K sh
Own New
-
Grant·A
Bryan Giraudo KEY
COO/CFO
$0
115.8K sh
Own +42%
-
Grant·A
Director
$0
3.8K sh
Own New
-
Grant·A
Director
$0
2.7K sh
Own +6%
-
Grant·A
Director
$0
3.8K sh
Own New
-
Grant·A
Director
$0
2.7K sh
Own +53%
-
Grant·A
Director
$0
3.8K sh
Own New
-
Grant·A
Director
$0
2.7K sh
Own +53%
-
Grant·A
President and CEO
$0
120.2K sh
Own New
-
Grant·A
President and CEO
$0
95.4K sh
Own +18%
-
Grant·A
Director
$0
3.8K sh
Own New
-
Grant·A
Director
$0
2.7K sh
Own +53%
-
Grant·A
Chief Medical Officer
$0
32.0K sh
Own New
-
Grant·A
Chief Medical Officer
$0
25.6K sh
Own +32%
-
Grant·A
Director
$0
3.8K sh
Own New
-
Grant·A
Director
$0
2.7K sh
Own +18%
-
Grant·A
Asif Ali KEY
Chief Financial Officer
$0
32.0K sh
Own New
-
Grant·A
Asif Ali KEY
Chief Financial Officer
$0
25.6K sh
Own +42%
| Date▾ | Insider | Type | Shares | Value |
|---|---|---|---|---|
| Jun 10, 2026 | William D. Waddill 10b5-1 | Exercise M | 6.0K | $0 |
| Jun 10, 2026 | William D. Waddill 10b5-1 | Exercise M | 3.0K | $0 |
| Jun 10, 2026 | William D. Waddill 10b5-1 | Sell S | 9.0K | $969.1K |
| Jun 10, 2026 | William D. Waddill 10b5-1 | Exercise M | 6.0K | $99.2K |
| Jun 10, 2026 | William D. Waddill 10b5-1 | Exercise M | 3.0K | $35.4K |
| May 29, 2026 | William D. Waddill 10b5-1 | Exercise M | 9.0K | $0 |
| May 29, 2026 | William D. Waddill 10b5-1 | Sell S | 9.0K | $896.8K |
| May 29, 2026 | William D. Waddill 10b5-1 | Exercise M | 9.0K | $106.2K |
| May 12, 2026 | PATEL DINESH V PH D KEY | Exercise M | 75.0K | $0 |
| May 12, 2026 | PATEL DINESH V PH D KEY | Sell S | 75.0K | $7.5M |
| May 12, 2026 | PATEL DINESH V PH D KEY | Exercise M | 75.0K | $1.6M |
| May 12, 2026 | PATEL DINESH V PH D KEY 10b5-1 | Exercise M | 75.0K | $0 |
| May 12, 2026 | PATEL DINESH V PH D KEY 10b5-1 | Sell S | 75.0K | $7.5M |
| May 12, 2026 | PATEL DINESH V PH D KEY 10b5-1 | Exercise M | 75.0K | $1.6M |
| May 8, 2026 | Bryan Giraudo | Sell S | 5.1K | $513.0K |
| May 8, 2026 | Bryan Giraudo | Sell S | 6.0K | $600.0K |
| May 7, 2026 | Bryan Giraudo | Exercise M | 12.0K | $0 |
| May 7, 2026 | Bryan Giraudo | Exercise M | 24.0K | $0 |
| May 7, 2026 | Bryan Giraudo | Sell S | 12.0K | $1.2M |
| May 7, 2026 | Bryan Giraudo | Sell S | 36.0K | $3.6M |
| May 7, 2026 | Bryan Giraudo | Exercise M | 12.0K | $83.8K |
| May 7, 2026 | Bryan Giraudo | Exercise M | 24.0K | $154.8K |
| Apr 23, 2026 | PATEL DINESH V PH D KEY | Other G | 1.5K | $0 |
| Apr 20, 2026 | Asif Ali KEY | Sell S | 1.8K | $184.6K |
| Mar 26, 2026 | Harold E Selick | Exercise M | 24.0K | $0 |
| Mar 26, 2026 | Harold E Selick | Sell S | 24.0K | $2.5M |
| Mar 26, 2026 | Harold E Selick | Exercise M | 24.0K | $309.1K |
| Mar 26, 2026 | Arturo Molina MD | Exercise M | 15.0K | $0 |
| Mar 26, 2026 | Arturo Molina MD | Sell S | 15.0K | $1.6M |
| Mar 26, 2026 | Arturo Molina MD | Exercise M | 15.0K | $120.6K |
| Mar 26, 2026 | Asif Ali KEY | Exercise M | 5.3K | $0 |
| Mar 26, 2026 | Asif Ali KEY | Exercise M | 19.5K | $0 |
| Mar 26, 2026 | Asif Ali KEY | Sell S | 24.8K | $2.6M |
| Mar 26, 2026 | Asif Ali KEY | Exercise M | 5.3K | $64.1K |
| Mar 26, 2026 | Asif Ali KEY | Exercise M | 19.5K | $374.2K |
| Mar 25, 2026 | PATEL DINESH V PH D KEY | Exercise M | 54.6K | $0 |
| Mar 25, 2026 | PATEL DINESH V PH D KEY | Sell S | 54.6K | $5.5M |
| Mar 25, 2026 | PATEL DINESH V PH D KEY | Exercise M | 54.6K | $468.8K |
| Mar 24, 2026 | PATEL DINESH V PH D KEY | Exercise M | 59 | $0 |
| Mar 24, 2026 | PATEL DINESH V PH D KEY | Sell S | 59 | $6.0K |
| Mar 24, 2026 | PATEL DINESH V PH D KEY | Exercise M | 59 | $506 |
| Mar 23, 2026 | PATEL DINESH V PH D KEY | Other G | 50.0K | $0 |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 96.7K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 47.7K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 60.0K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 100.0K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 176.7K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 211.5K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 181.2K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 543.8K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 638.0K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Grant A | 693.8K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 96.7K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 47.7K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 60.0K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 100.0K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 176.7K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 211.5K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 181.2K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 543.8K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 638.0K | — |
| Mar 19, 2026 | Bryan Giraudo KEY | Other D | 693.8K | — |
| Feb 17, 2026 | Lewis T Williams | Exercise M | 18.0K | $0 |
| Feb 17, 2026 | Lewis T Williams | Sell S | 18.0K | $1.5M |
| Feb 17, 2026 | Lewis T Williams | Exercise M | 18.0K | $195.1K |
| Feb 6, 2026 | William D. Waddill | Exercise M | 20.0K | $0 |
| Feb 6, 2026 | William D. Waddill | Sell S | 20.0K | $1.7M |
| Feb 6, 2026 | William D. Waddill | Exercise M | 20.0K | $166.2K |
| Jan 27, 2026 | PATEL DINESH V PH D KEY | Exercise M | 4.1K | $0 |
| Jan 27, 2026 | PATEL DINESH V PH D KEY | Sell S | 4.1K | $338.4K |
| Jan 27, 2026 | PATEL DINESH V PH D KEY | Exercise M | 4.1K | $87.8K |
| Jan 27, 2026 | Arturo Molina MD | Exercise M | 5.0K | $0 |
| Jan 27, 2026 | Arturo Molina MD | Sell S | 5.0K | $410.0K |
| Jan 27, 2026 | Arturo Molina MD | Exercise M | 5.0K | $40.2K |
| Jan 27, 2026 | Asif Ali KEY | Exercise M | 12.0K | $0 |
| Jan 27, 2026 | Asif Ali KEY | Exercise M | 16.0K | $0 |
| Jan 27, 2026 | Asif Ali KEY | Sell S | 18.2K | $1.5M |
| Jan 27, 2026 | Asif Ali KEY | Sell S | 28.0K | $2.3M |
| Jan 27, 2026 | Asif Ali KEY | Exercise M | 12.0K | $146.0K |
| Jan 27, 2026 | Asif Ali KEY | Exercise M | 16.0K | $307.0K |
| Jan 26, 2026 | PATEL DINESH V PH D KEY | Exercise M | 14.2K | $0 |
| Jan 26, 2026 | PATEL DINESH V PH D KEY | Exercise M | 10.7K | $0 |
| Jan 26, 2026 | PATEL DINESH V PH D KEY | Sell S | 14.2K | $1.2M |
| Jan 26, 2026 | PATEL DINESH V PH D KEY | Exercise M | 14.2K | $306.5K |
| Jan 26, 2026 | PATEL DINESH V PH D KEY | Sell S | 10.7K | $897.5K |
| Jan 26, 2026 | PATEL DINESH V PH D KEY | Exercise M | 10.7K | $45.0K |
| Jan 26, 2026 | Arturo Molina MD | Exercise M | 5.0K | $0 |
| Jan 26, 2026 | Arturo Molina MD | Sell S | 5.0K | $411.4K |
| Jan 26, 2026 | Arturo Molina MD | Exercise M | 5.0K | $40.2K |
| Jan 23, 2026 | PATEL DINESH V PH D KEY | Exercise M | 19.3K | $0 |
| Jan 23, 2026 | PATEL DINESH V PH D KEY | Sell S | 19.3K | $1.6M |
| Jan 23, 2026 | PATEL DINESH V PH D KEY | Exercise M | 19.3K | $81.3K |
| Jan 23, 2026 | PATEL DINESH V PH D KEY | Other G | 6.0K | $0 |
| Jan 23, 2026 | Arturo Molina MD | Sell S | 13.2K | $1.1M |
| Jan 20, 2026 | PATEL DINESH V PH D KEY | Sell S | 34.4K | $2.8M |
| Jan 20, 2026 | Arturo Molina MD | Sell S | 9.5K | $784.7K |
| Jan 20, 2026 | Asif Ali KEY | Sell S | 8.6K | $708.3K |
| Jan 9, 2026 | Harold E Selick | Exercise M | 14.3K | $0 |
| Jan 9, 2026 | Harold E Selick | Exercise M | 14.3K | $60.2K |
| Jan 2, 2026 | Bryan Giraudo KEY | Grant A | 693.8K | $0 |
| Jan 2, 2026 | Bryan Giraudo KEY | Grant A | 115.8K | $0 |
| Jan 2, 2026 | Harold E Selick | Grant A | 3.8K | $0 |
| Jan 2, 2026 | Harold E Selick | Grant A | 2.7K | $0 |
| Jan 2, 2026 | William D. Waddill | Grant A | 3.8K | $0 |
| Jan 2, 2026 | William D. Waddill | Grant A | 2.7K | $0 |
| Jan 2, 2026 | Lewis T Williams | Grant A | 3.8K | $0 |
| Jan 2, 2026 | Lewis T Williams | Grant A | 2.7K | $0 |
| Jan 2, 2026 | PATEL DINESH V PH D KEY | Grant A | 120.2K | $0 |
| Jan 2, 2026 | PATEL DINESH V PH D KEY | Grant A | 95.4K | $0 |
| Jan 2, 2026 | Sarah A O'Dowd | Grant A | 3.8K | $0 |
| Jan 2, 2026 | Sarah A O'Dowd | Grant A | 2.7K | $0 |
| Jan 2, 2026 | Arturo Molina MD | Grant A | 32.0K | $0 |
| Jan 2, 2026 | Arturo Molina MD | Grant A | 25.6K | $0 |
| Jan 2, 2026 | Bryan Giraudo | Grant A | 3.8K | $0 |
| Jan 2, 2026 | Bryan Giraudo | Grant A | 2.7K | $0 |
| Jan 2, 2026 | Asif Ali KEY | Grant A | 32.0K | $0 |
| Jan 2, 2026 | Asif Ali KEY | Grant A | 25.6K | $0 |
About PTGX insider trading
This page tracks insider transactions for Protagonist Therapeutics, Inc (PTGX) reported to the U.S. Securities and Exchange Commission on Form 4. Corporate insiders — directors, executive officers and beneficial owners of more than 10% of the stock — must disclose their trades within two business days. Open-market purchases (code P) and sales (code S) made at the insider's discretion are the most-watched opportunistic signals, while awards (A), option exercises (M) and tax-withholding (F) reflect compensation rather than conviction. Trades marked 10b5-1 were made under a pre-arranged plan and are considered routine. A cluster buy — several insiders buying within a short window — is historically a stronger bullish indicator than any single trade.