SPRB

insider transactions

SPRUCE BIOSCIENCES, INC. — buys & sells by directors, officers and 10% owners (SEC Form 4).

30D 90D 1Y

Net shares · 365d

-2

512 buy · 514 sell

Net value · 365d

-$672

$9.2K in · $9.8K out

Sentiment · 365d

Net selling

48% buying · 52% selling

Open-market trades · 365d

512 buy · 514 sell

Net buy / sell volume

Tap or hover the chart for daily net volume. Green = net buying, red = net selling.

All transactions

Grant·A
May 21, 26

Walbert Keli

Director

$0

1.7K sh

Own New
Grant·A
May 21, 26

SPIEGELMAN DANIEL K

Director

$0

1.7K sh

Own New
Grant·A
May 21, 26

SIMPSON CAMILLA V

Director

$0

1.7K sh

Own New
Grant·A
May 21, 26

GREY MICHAEL G KEY

Executive Chairman

$0

1.7K sh

Own New
Grant·A
May 21, 26

Barretto-Ko Percival

Director

$0

1.7K sh

Own New
Grant·A
Mar 9, 26

Hooks Corwin Dale

Chief Commercial Officer

$0

11.0K sh

Own New
Grant·A
Dec 31, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$21.2K

4.7K sh · $4.53

Own +33%
Exercise·M
Dec 15, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

1.2K sh

Own +100%
Exercise·M
Dec 15, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

1.5K sh

Own New
Exercise·M
Dec 15, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

1.2K sh

Own +9%
Exercise·M
Dec 15, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

1.5K sh

Own +11%
Other·F
Dec 15, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$49.0K

608 sh · $80.67

Own -4%
Other·F
Dec 15, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$60.7K

752 sh · $80.67

Own -5%
Exercise·M
Dec 15, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

496 sh

Own +49600%
Exercise·M
Dec 15, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

513 sh

Own +100%
Other·F
Dec 15, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$14.8K

184 sh · $80.67

Own -2%
Exercise·M
Dec 15, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

513 sh

Own +6%
Other·F
Dec 15, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$14.4K

178 sh · $80.67

Own -2%
Exercise·M
Dec 15, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

496 sh

Own +7%
Other·D
Dec 11, 25

Ways Kirk

Interim Chief Medical Officer

—

400 sh

Own -100%
Grant·A
Dec 11, 25

Ways Kirk

Interim Chief Medical Officer

—

400 sh

Own New
Other·D
Dec 11, 25

Ways Kirk

Interim Chief Medical Officer

—

266 sh

Own -100%
Grant·A
Dec 11, 25

Ways Kirk

Interim Chief Medical Officer

—

266 sh

Own New
Grant·A
Dec 11, 25

Ways Kirk

Interim Chief Medical Officer

$0

5.0K sh

Own New
Exercise·M
Dec 11, 25

Ways Kirk

Interim Chief Medical Officer

$0

1.2K sh

Own +50%
Exercise·M
Dec 11, 25

Ways Kirk

Interim Chief Medical Officer

$0

1.2K sh

Own New
Grant·A
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

7.6K sh

Own New
Exercise·M
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

1.9K sh

Own +50%
Other·F
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$60.1K

680 sh · $88.41

Own -8%
Exercise·M
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

1.9K sh

Own +30%
Exercise·M
Dec 11, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

5.0K sh

Own +50%
Grant·A
Dec 11, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

19.8K sh

Own New
Exercise·M
Dec 11, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

5.0K sh

Own +48%
Other·F
Dec 11, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$194.0K

2.2K sh · $88.41

Own -14%
Other·D
Dec 11, 25

SPIEGELMAN DANIEL K

Director

—

400 sh

Own -100%
Other·D
Dec 11, 25

SPIEGELMAN DANIEL K

Director

—

458 sh

Own -100%
Grant·A
Dec 11, 25

SPIEGELMAN DANIEL K

Director

—

458 sh

Own New
Grant·A
Dec 11, 25

SPIEGELMAN DANIEL K

Director

—

88 sh

Own New
Grant·A
Dec 11, 25

SPIEGELMAN DANIEL K

Director

—

400 sh

Own New
Other·D
Dec 11, 25

SPIEGELMAN DANIEL K

Director

—

88 sh

Own -100%
Grant·A
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

666 sh

Own New
Other·D
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

133 sh

Own -100%
Grant·A
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

133 sh

Own New
Other·D
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

1.5K sh

Own -100%
Grant·A
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

1.5K sh

Own New
Other·D
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

1.3K sh

Own -100%
Grant·A
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

1.3K sh

Own New
Other·D
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

387 sh

Own -100%
Grant·A
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

387 sh

Own New
Other·D
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

400 sh

Own -100%
Grant·A
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

400 sh

Own New
Other·D
Dec 11, 25

GREY MICHAEL G KEY

Executive Chairman

—

666 sh

Own -100%
Grant·A
Dec 11, 25

Walbert Keli

Director

$0

3.4K sh

Own New
Grant·A
Dec 11, 25

Barretto-Ko Percival

Director

—

800 sh

Own New
Other·D
Dec 11, 25

Barretto-Ko Percival

Director

—

800 sh

Own -100%
Grant·A
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

733 sh

Own New
Grant·A
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

933 sh

Own New
Other·D
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

1.9K sh

Own -100%
Grant·A
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

1.9K sh

Own New
Other·D
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

733 sh

Own -100%
Other·D
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

933 sh

Own -100%
Other·D
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

953 sh

Own -100%
Grant·A
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

953 sh

Own New
Other·D
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

1.6K sh

Own -100%
Grant·A
Dec 11, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

—

1.6K sh

Own New
Grant·A
Dec 11, 25

SIMPSON CAMILLA V

Director

—

362 sh

Own New
Grant·A
Dec 11, 25

SIMPSON CAMILLA V

Director

—

400 sh

Own New
Other·D
Dec 11, 25

SIMPSON CAMILLA V

Director

—

133 sh

Own -100%
Grant·A
Dec 11, 25

SIMPSON CAMILLA V

Director

—

133 sh

Own New
Other·D
Dec 11, 25

SIMPSON CAMILLA V

Director

—

362 sh

Own -100%
Other·D
Dec 11, 25

SIMPSON CAMILLA V

Director

—

400 sh

Own -100%
Other·D
Dec 11, 25

SIMPSON CAMILLA V

Director

—

309 sh

Own -100%
Grant·A
Dec 11, 25

SIMPSON CAMILLA V

Director

—

309 sh

Own New
Other·D
Dec 11, 25

SIMPSON CAMILLA V

Director

—

173 sh

Own -100%
Grant·A
Dec 11, 25

SIMPSON CAMILLA V

Director

—

173 sh

Own New
Other·D
Dec 11, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

—

10.0K sh

Own -100%
Grant·A
Dec 11, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

—

10.0K sh

Own New
Other·D
Dec 11, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

—

1.7K sh

Own -100%
Grant·A
Dec 11, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

—

1.7K sh

Own New
Exercise·M
Dec 10, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

514 sh

Own +50%
Other·F
Dec 10, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$15.8K

184 sh · $85.67

Own -3%
Exercise·M
Dec 10, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

514 sh

Own +8%
Exercise·M
Dec 10, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

1.2K sh

Own +50%
Exercise·M
Dec 10, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

1.2K sh

Own +13%
Other·F
Dec 10, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$36.7K

428 sh · $85.67

Own -4%
Exercise·M
Oct 20, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

2.1K sh

Own New
Grant·A
Oct 20, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

2.1K sh

Own New
Other·F
Oct 20, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$97.9K

661 sh · $148.16

Own -10%
Exercise·M
Oct 20, 25

Gharib Samir M. KEY

PRESIDENT AND CFO

$0

2.1K sh

Own +44%
Grant·A
Oct 20, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

4.8K sh

Own New
Exercise·M
Oct 20, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

4.8K sh

Own New
Other·F
Oct 20, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$228.0K

1.5K sh · $148.16

Own -14%
Exercise·M
Oct 20, 25

Szwarcberg Javier B. KEY

CHIEF EXECUTIVE OFFICER

$0

4.8K sh

Own +77%
Buy·P
Oct 6, 25

Parkman Healthcare Partners LLC

TenPercentOwner

$4.6K

256 sh · $17.91

Own +24%
Sell·S
Oct 6, 25

Parkman Healthcare Partners LLC

TenPercentOwner

$436

25 sh · $17.46

Own -2%
Sell·S
Oct 6, 25

Parkman Healthcare Partners LLC

TenPercentOwner

$4.5K

232 sh · $19.33

Own -18%
Sell·S
Oct 6, 25

Parkman Healthcare Partners LLC

TenPercentOwner

$436

25 sh · $17.46

Own -2%
Buy·P
Oct 6, 25

Parkman Healthcare Partners LLC

TenPercentOwner

$4.6K

256 sh · $17.91

Own +24%
Sell·S
Oct 6, 25

Parkman Healthcare Partners LLC

TenPercentOwner

$4.5K

232 sh · $19.33

Own -18%
Grant·A
Jul 23, 25

Ways Kirk

Interim Chief Medical Officer

$0

30.0K sh

Own New
Grant·A
Jul 22, 25

Aynechi Tiba

Director

$0

30.0K sh

Own New
Grant·A
Jul 22, 25

Barretto-Ko Percival

Director

$0

30.0K sh

Own New
Grant·A
Jul 22, 25

GREY MICHAEL G KEY

Executive Chairman

$0

30.0K sh

Own New
Grant·A
Jul 22, 25

SPIEGELMAN DANIEL K

Director

$0

30.0K sh

Own New
Grant·A
Jul 22, 25

Muralidhar Bali

Director

$0

30.0K sh

Own New
Grant·A
Jul 22, 25

SIMPSON CAMILLA V

Director

$0

30.0K sh

Own New

Date▾	Insider	Role	Type	Shares	Own Δ	Price	Value
May 21, 2026	Walbert Keli	Director	Grant A	1.7K	New	—	$0
May 21, 2026	SPIEGELMAN DANIEL K	Director	Grant A	1.7K	New	—	$0
May 21, 2026	SIMPSON CAMILLA V	Director	Grant A	1.7K	New	—	$0
May 21, 2026	GREY MICHAEL G KEY	Executive Chairman	Grant A	1.7K	New	—	$0
May 21, 2026	Barretto-Ko Percival	Director	Grant A	1.7K	New	—	$0
Mar 9, 2026	Hooks Corwin Dale	Chief Commercial Officer	Grant A	11.0K	New	—	$0
Dec 31, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Grant A	4.7K	+33%	$4.53	$21.2K
Dec 15, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	1.2K	+100%	—	$0
Dec 15, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	1.5K	New	—	$0
Dec 15, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	1.2K	+9%	—	$0
Dec 15, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	1.5K	+11%	—	$0
Dec 15, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Other F	608	-4%	$80.67	$49.0K
Dec 15, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Other F	752	-5%	$80.67	$60.7K
Dec 15, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	496	+49600%	—	$0
Dec 15, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	513	+100%	—	$0
Dec 15, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other F	184	-2%	$80.67	$14.8K
Dec 15, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	513	+6%	—	$0
Dec 15, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other F	178	-2%	$80.67	$14.4K
Dec 15, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	496	+7%	—	$0
Dec 11, 2025	Ways Kirk	Interim Chief Medical Officer	Other D	400	-100%	—	—
Dec 11, 2025	Ways Kirk	Interim Chief Medical Officer	Grant A	400	New	—	—
Dec 11, 2025	Ways Kirk	Interim Chief Medical Officer	Other D	266	-100%	—	—
Dec 11, 2025	Ways Kirk	Interim Chief Medical Officer	Grant A	266	New	—	—
Dec 11, 2025	Ways Kirk	Interim Chief Medical Officer	Grant A	5.0K	New	—	$0
Dec 11, 2025	Ways Kirk	Interim Chief Medical Officer	Exercise M	1.2K	+50%	—	$0
Dec 11, 2025	Ways Kirk	Interim Chief Medical Officer	Exercise M	1.2K	New	—	$0
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Grant A	7.6K	New	—	$0
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	1.9K	+50%	—	$0
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other F	680	-8%	$88.41	$60.1K
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	1.9K	+30%	—	$0
Dec 11, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	5.0K	+50%	—	$0
Dec 11, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Grant A	19.8K	New	—	$0
Dec 11, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	5.0K	+48%	—	$0
Dec 11, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Other F	2.2K	-14%	$88.41	$194.0K
Dec 11, 2025	SPIEGELMAN DANIEL K	Director	Other D	400	-100%	—	—
Dec 11, 2025	SPIEGELMAN DANIEL K	Director	Other D	458	-100%	—	—
Dec 11, 2025	SPIEGELMAN DANIEL K	Director	Grant A	458	New	—	—
Dec 11, 2025	SPIEGELMAN DANIEL K	Director	Grant A	88	New	—	—
Dec 11, 2025	SPIEGELMAN DANIEL K	Director	Grant A	400	New	—	—
Dec 11, 2025	SPIEGELMAN DANIEL K	Director	Other D	88	-100%	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Grant A	666	New	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Other D	133	-100%	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Grant A	133	New	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Other D	1.5K	-100%	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Grant A	1.5K	New	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Other D	1.3K	-100%	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Grant A	1.3K	New	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Other D	387	-100%	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Grant A	387	New	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Other D	400	-100%	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Grant A	400	New	—	—
Dec 11, 2025	GREY MICHAEL G KEY	Executive Chairman	Other D	666	-100%	—	—
Dec 11, 2025	Walbert Keli	Director	Grant A	3.4K	New	—	$0
Dec 11, 2025	Barretto-Ko Percival	Director	Grant A	800	New	—	—
Dec 11, 2025	Barretto-Ko Percival	Director	Other D	800	-100%	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Grant A	733	New	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Grant A	933	New	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other D	1.9K	-100%	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Grant A	1.9K	New	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other D	733	-100%	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other D	933	-100%	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other D	953	-100%	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Grant A	953	New	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other D	1.6K	-100%	—	—
Dec 11, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Grant A	1.6K	New	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Grant A	362	New	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Grant A	400	New	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Other D	133	-100%	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Grant A	133	New	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Other D	362	-100%	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Other D	400	-100%	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Other D	309	-100%	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Grant A	309	New	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Other D	173	-100%	—	—
Dec 11, 2025	SIMPSON CAMILLA V	Director	Grant A	173	New	—	—
Dec 11, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Other D	10.0K	-100%	—	—
Dec 11, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Grant A	10.0K	New	—	—
Dec 11, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Other D	1.7K	-100%	—	—
Dec 11, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Grant A	1.7K	New	—	—
Dec 10, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	514	+50%	—	$0
Dec 10, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other F	184	-3%	$85.67	$15.8K
Dec 10, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	514	+8%	—	$0
Dec 10, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	1.2K	+50%	—	$0
Dec 10, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	1.2K	+13%	—	$0
Dec 10, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Other F	428	-4%	$85.67	$36.7K
Oct 20, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	2.1K	New	—	$0
Oct 20, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Grant A	2.1K	New	—	$0
Oct 20, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Other F	661	-10%	$148.16	$97.9K
Oct 20, 2025	Gharib Samir M. KEY	PRESIDENT AND CFO	Exercise M	2.1K	+44%	—	$0
Oct 20, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Grant A	4.8K	New	—	$0
Oct 20, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	4.8K	New	—	$0
Oct 20, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Other F	1.5K	-14%	$148.16	$228.0K
Oct 20, 2025	Szwarcberg Javier B. KEY	CHIEF EXECUTIVE OFFICER	Exercise M	4.8K	+77%	—	$0
Oct 6, 2025	Parkman Healthcare Partners LLC	TenPercentOwner	Buy P	256	+24%	$17.91	$4.6K
Oct 6, 2025	Parkman Healthcare Partners LLC	TenPercentOwner	Sell S	25	-2%	$17.46	$436
Oct 6, 2025	Parkman Healthcare Partners LLC	TenPercentOwner	Sell S	232	-18%	$19.33	$4.5K
Oct 6, 2025	Parkman Healthcare Partners LLC	TenPercentOwner	Sell S	25	-2%	$17.46	$436
Oct 6, 2025	Parkman Healthcare Partners LLC	TenPercentOwner	Buy P	256	+24%	$17.91	$4.6K
Oct 6, 2025	Parkman Healthcare Partners LLC	TenPercentOwner	Sell S	232	-18%	$19.33	$4.5K
Jul 23, 2025	Ways Kirk	Interim Chief Medical Officer	Grant A	30.0K	New	—	$0
Jul 22, 2025	Aynechi Tiba	Director	Grant A	30.0K	New	—	$0
Jul 22, 2025	Barretto-Ko Percival	Director	Grant A	30.0K	New	—	$0
Jul 22, 2025	GREY MICHAEL G KEY	Executive Chairman	Grant A	30.0K	New	—	$0
Jul 22, 2025	SPIEGELMAN DANIEL K	Director	Grant A	30.0K	New	—	$0
Jul 22, 2025	Muralidhar Bali	Director	Grant A	30.0K	New	—	$0
Jul 22, 2025	SIMPSON CAMILLA V	Director	Grant A	30.0K	New	—	$0

About SPRB insider trading

This page tracks insider transactions for SPRUCE BIOSCIENCES, INC. (SPRB) reported to the U.S. Securities and Exchange Commission on Form 4. Corporate insiders — directors, executive officers and beneficial owners of more than 10% of the stock — must disclose their trades within two business days. Open-market purchases (code P) and sales (code S) made at the insider's discretion are the most-watched opportunistic signals, while awards (A), option exercises (M) and tax-withholding (F) reflect compensation rather than conviction. Trades marked 10b5-1 were made under a pre-arranged plan and are considered routine. A cluster buy — several insiders buying within a short window — is historically a stronger bullish indicator than any single trade.