SYRE
insider transactionsSpyre Therapeutics, Inc. — buys & sells by directors, officers and 10% owners A shareholder owning more than 10% of the company. Must report trades, but usually a weaker signal than an officer or director. (SEC Form 4).
Net shares · 365d
-294.6K
0 buy · 294.6K sell
Net value · 365d
-$18.9M
$0 in · $18.9M out
Sentiment · 365d
Net selling
0% buying · 100% selling
Open-market trades · 365d
39
0 buy · 294.6K sell
Net buy / sell volume
Not enough data to chart yet.
Tap or hover the chart for daily net volume. Green = net buying, red = net selling.
All transactions
-
Exercise·M
Chief Medical Officer · 10b5-1
$0
8.3K sh
Own +3%
-
Sell·S
Chief Medical Officer · 10b5-1
$625.0K
8.3K sh · $75.00
Own -100%
-
Exercise·M
Chief Medical Officer · 10b5-1
$228.8K
8.3K sh · $27.46
Own New
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$235.1K
3.3K sh · $71.38
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$574.5K
8.1K sh · $70.50
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$246.9K
3.6K sh · $69.40
Own -1%
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$0
7.5K sh
Own +2%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$223.4K
3.1K sh · $72.06
Own -3%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$183.9K
2.6K sh · $70.77
Own -3%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$125.6K
1.8K sh · $69.75
Own -2%
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$108.8K
7.5K sh · $14.50
Own +8%
-
Grant·A
Director
$0
8.0K sh
Own New
-
Grant·A
Director
$0
8.0K sh
Own New
-
Grant·A
Director
$0
8.0K sh
Own New
-
Grant·A
Director
$0
8.0K sh
Own New
-
Grant·A
Director
$0
8.0K sh
Own New
-
Sell·S
Director · 10b5-1
$1.5M
19.3K sh · $75.35
Own -18%
-
Sell·S
Director · 10b5-1
$1.9M
24.8K sh · $74.76
Own -19%
-
Sell·S
Director · 10b5-1
$2.5M
33.5K sh · $73.72
Own -20%
-
Sell·S
Director · 10b5-1
$174.5K
2.4K sh · $72.57
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$22.5K
300 sh · $74.96
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$126.2K
1.7K sh · $74.23
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$226.7K
3.1K sh · $73.14
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$71.8K
1.0K sh · $71.76
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$254.8K
3.6K sh · $70.77
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$368.6K
5.3K sh · $69.54
Own -1%
-
Exercise·M
Chief Medical Officer · 10b5-1
$0
78.3K sh
Own +32%
-
Sell·S
Chief Medical Officer · 10b5-1
$30.1K
400 sh · $75.37
Own -100%
-
Sell·S
Chief Medical Officer · 10b5-1
$377.4K
5.1K sh · $74.60
Own -93%
-
Sell·S
Chief Medical Officer · 10b5-1
$763.8K
10.4K sh · $73.74
Own -65%
-
Sell·S
Chief Medical Officer · 10b5-1
$932.0K
12.8K sh · $72.94
Own -45%
-
Sell·S
Chief Medical Officer · 10b5-1
$628.1K
8.8K sh · $71.56
Own -23%
-
Sell·S
Chief Medical Officer · 10b5-1
$1.4M
19.7K sh · $70.61
Own -34%
-
Sell·S
Chief Medical Officer · 10b5-1
$1.5M
21.3K sh · $69.53
Own -27%
-
Exercise·M
Chief Medical Officer · 10b5-1
$2.2M
78.3K sh · $27.46
Own New
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$0
12.5K sh
Own +3%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$892.1K
12.5K sh · $71.37
Own -11%
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$181.2K
12.5K sh · $14.50
Own +13%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$132.6K
2.7K sh · $49.92
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$607.3K
12.3K sh · $49.20
Own -2%
-
Exercise·M
Chief Medical Officer · 10b5-1
$0
8.0K sh
Own +10%
-
Sell·S
Chief Medical Officer · 10b5-1
$397.9K
8.0K sh · $50.00
Own -100%
-
Exercise·M
Chief Medical Officer · 10b5-1
$172.4K
8.0K sh · $21.66
Own New
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$0
7.5K sh
Own +2%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$65.0K
1.3K sh · $49.98
Own -1%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$305.1K
6.2K sh · $49.21
Own -6%
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$108.8K
7.5K sh · $14.50
Own +8%
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$0
2.5K sh
Own +1%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$8.3K
200 sh · $41.66
Own -0%
-
Sell·S
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$93.3K
2.3K sh · $40.56
Own -2%
-
Exercise·M
Scott L Burrows KEY
Chief Financial Officer · 10b5-1
$36.2K
2.5K sh · $14.50
Own +3%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$386.7K
9.1K sh · $42.49
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$246.2K
5.9K sh · $41.73
Own -1%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$461.6K
14.0K sh · $32.87
Own -2%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$30.5K
957 sh · $31.82
Own -0%
-
Other·J
Director
$0
63.2K sh
-
Grant·A
Cameron Turtle KEY
Chief Executive Officer
$0
528.0K sh
Own New
-
Grant·A
Chief Medical Officer
$0
140.0K sh
Own New
-
Grant·A
Chief Legal Officer and Corpo…
$0
140.0K sh
Own New
-
Grant·A
Scott L Burrows KEY
Chief Financial Officer
$0
140.0K sh
Own New
-
Grant·A
Director
$0
15.3K sh
Own New
-
Grant·A
Director
—
3.4K sh
Own +49%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$3.2K
100 sh · $32.39
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$69.7K
2.2K sh · $31.79
Own -0%
-
Sell·S
Cameron Turtle KEY
Chief Executive Officer · 10b5-1
$387.2K
12.7K sh · $30.47
Own -2%
| Date▾ | Insider | Type | Shares | Value |
|---|---|---|---|---|
| Jun 3, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 8.3K | $0 |
| Jun 3, 2026 | Sheldon Sloan 10b5-1 | Sell S | 8.3K | $625.0K |
| Jun 3, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 8.3K | $228.8K |
| Jun 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 3.3K | $235.1K |
| Jun 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 8.1K | $574.5K |
| Jun 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 3.6K | $246.9K |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 7.5K | $0 |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 3.1K | $223.4K |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 2.6K | $183.9K |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 1.8K | $125.6K |
| Jun 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 7.5K | $108.8K |
| May 27, 2026 | Laurie Stelzer | Grant A | 8.0K | $0 |
| May 27, 2026 | Sandra Milligan | Grant A | 8.0K | $0 |
| May 27, 2026 | Mark C. Mckenna | Grant A | 8.0K | $0 |
| May 27, 2026 | Michael Thomas Henderson | Grant A | 8.0K | $0 |
| May 27, 2026 | Jeffrey W. Albers | Grant A | 8.0K | $0 |
| May 8, 2026 | Michael Thomas Henderson 10b5-1 | Sell S | 19.3K | $1.5M |
| May 8, 2026 | Michael Thomas Henderson 10b5-1 | Sell S | 24.8K | $1.9M |
| May 8, 2026 | Michael Thomas Henderson 10b5-1 | Sell S | 33.5K | $2.5M |
| May 8, 2026 | Michael Thomas Henderson 10b5-1 | Sell S | 2.4K | $174.5K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 300 | $22.5K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 1.7K | $126.2K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 3.1K | $226.7K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 1.0K | $71.8K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 3.6K | $254.8K |
| May 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 5.3K | $368.6K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 78.3K | $0 |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 400 | $30.1K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 5.1K | $377.4K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 10.4K | $763.8K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 12.8K | $932.0K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 8.8K | $628.1K |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 19.7K | $1.4M |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 21.3K | $1.5M |
| May 1, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 78.3K | $2.2M |
| May 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 12.5K | $0 |
| May 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 12.5K | $892.1K |
| May 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 12.5K | $181.2K |
| Apr 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 2.7K | $132.6K |
| Apr 1, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 12.3K | $607.3K |
| Apr 1, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 8.0K | $0 |
| Apr 1, 2026 | Sheldon Sloan 10b5-1 | Sell S | 8.0K | $397.9K |
| Apr 1, 2026 | Sheldon Sloan 10b5-1 | Exercise M | 8.0K | $172.4K |
| Apr 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 7.5K | $0 |
| Apr 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 1.3K | $65.0K |
| Apr 1, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 6.2K | $305.1K |
| Apr 1, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 7.5K | $108.8K |
| Mar 3, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 2.5K | $0 |
| Mar 3, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 200 | $8.3K |
| Mar 3, 2026 | Scott L Burrows KEY 10b5-1 | Sell S | 2.3K | $93.3K |
| Mar 3, 2026 | Scott L Burrows KEY 10b5-1 | Exercise M | 2.5K | $36.2K |
| Mar 2, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 9.1K | $386.7K |
| Mar 2, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 5.9K | $246.2K |
| Feb 2, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 14.0K | $461.6K |
| Feb 2, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 957 | $30.5K |
| Jan 21, 2026 | Michael Thomas Henderson | Other J | 63.2K | $0 |
| Jan 9, 2026 | Cameron Turtle KEY | Grant A | 528.0K | $0 |
| Jan 9, 2026 | Sheldon Sloan | Grant A | 140.0K | $0 |
| Jan 9, 2026 | Heidy King-Jones | Grant A | 140.0K | $0 |
| Jan 9, 2026 | Scott L Burrows KEY | Grant A | 140.0K | $0 |
| Jan 7, 2026 | Mark C. Mckenna | Grant A | 15.3K | $0 |
| Jan 7, 2026 | Mark C. Mckenna | Grant A | 3.4K | — |
| Jan 2, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 100 | $3.2K |
| Jan 2, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 2.2K | $69.7K |
| Jan 2, 2026 | Cameron Turtle KEY 10b5-1 | Sell S | 12.7K | $387.2K |
About SYRE insider trading
This page tracks insider transactions for Spyre Therapeutics, Inc. (SYRE) reported to the U.S. Securities and Exchange Commission on Form 4. Corporate insiders — directors, executive officers and beneficial owners of more than 10% of the stock — must disclose their trades within two business days. Open-market purchases (code P) and sales (code S) made at the insider's discretion are the most-watched opportunistic signals, while awards (A), option exercises (M) and tax-withholding (F) reflect compensation rather than conviction. Trades marked 10b5-1 were made under a pre-arranged plan and are considered routine. A cluster buy — several insiders buying within a short window — is historically a stronger bullish indicator than any single trade.