Opaleye Management Inc.

Insider

10% Owner

Trades at: ACOG· SLGL· SNWV· HROW· CDXS· ETON· TARA· TCON +1 more

30D 90D 1Y

Net shares · 365d

-3.6M

983.3K buy · 4.6M sell

Net value · 365d

-$7.9M

$11.1M in · $19.0M out

Sentiment · 365d

Net selling

37% buying · 63% selling

Open-market trades · 365d

118

983.3K buy · 4.6M sell

Trading track record · all companies

Running net of open-market buys − sells across every company. Tap the line or a marker for details. ▲ buy · ▼ sell.

Transactions · 365d

Open-market Buys Sells All types

ACOG Buy·P
Jun 15, 26

10% Owner

$45.8K

7.7K sh · $5.96 avg · 3 lots

Own +0%
ACOG Buy·P
Jun 10, 26

10% Owner

$183.7K

30.7K sh · $5.98 avg · 2 lots

Own +1%
ACOG Buy·P
Jun 5, 26

10% Owner

$58.6K

10.1K sh · $5.83

Own +0%
ACOG Buy·P
May 29, 26

10% Owner

$434.7K

73.7K sh · $5.90 avg · 3 lots

Own +3%
ACOG Buy·P
May 21, 26

10% Owner

$140.5K

24.4K sh · $5.77 avg · 2 lots

Own +1%
SLGL Buy·P
May 20, 26

10% Owner

$100.7K

1.6K sh · $64.43

Own +0%
ACOG Buy·P
May 18, 26

10% Owner

$196.0K

34.0K sh · $5.76 avg · 2 lots

Own +1%
SLGL Buy·P
May 13, 26

10% Owner

$231.5K

3.4K sh · $67.36 avg · 2 lots

Own +1%
SNWV Sell·S
May 1, 26

10% Owner

$574.2K

35.6K sh · $16.14 avg · 4 lots

Own -88%
SNWV Sell·S
Apr 29, 26

10% Owner

$1.3M

70.6K sh · $18.05 avg · 4 lots

Own -92%
SNWV Sell·S
Apr 21, 26

10% Owner

$337.0K

16.5K sh · $20.46 avg · 3 lots

Own -2%
ACOG Buy·P
Mar 30, 26

TenPercentOwner

$60.0K

11.8K sh · $5.07 avg · 2 lots

Own +0%
ACOG Buy·P
Mar 26, 26

TenPercentOwner

$108.6K

20.1K sh · $5.41 avg · 3 lots

Own +1%
SLGL Buy·P
Mar 24, 26

TenPercentOwner

$2.9M

39.7K sh · $72.00 avg · 2 lots

Own New
ACOG Buy·P
Mar 19, 26

TenPercentOwner

$26.2K

4.6K sh · $5.73 avg · 2 lots

Own +0%
ACOG Buy·P
Mar 16, 26

TenPercentOwner

$7.7K

1.3K sh · $5.78

Own +0%
ACOG Buy·P
Mar 13, 26

TenPercentOwner

$75.7K

13.1K sh · $5.79 avg · 2 lots

Own +1%
ACOG Buy·P
Mar 9, 26

TenPercentOwner

$23.8K

4.1K sh · $5.83 avg · 2 lots

Own +0%
ACOG Buy·P
Mar 5, 26

TenPercentOwner

$387.7K

66.8K sh · $5.80 avg · 3 lots

Own +3%
HROW Sell·S
Mar 4, 26

TenPercentOwner

$7.8M

198.6K sh · $39.51 avg · 4 lots

Own -77%
ACOG Buy·P
Mar 3, 26

TenPercentOwner

$411.6K

71.4K sh · $5.76 avg · 3 lots

Own +3%
ACOG Buy·P
Feb 27, 26

TenPercentOwner

$25.3K

4.2K sh · $5.99 avg · 2 lots

Own +0%
HROW Sell·S
Feb 27, 26

TenPercentOwner

$270.9K

5.0K sh · $54.18

Own -7%
ACOG Buy·P
Feb 24, 26

TenPercentOwner

$1.0M

171.4K sh · $5.86 avg · 6 lots

Own New
SLGL Buy·P
Feb 13, 26

TenPercentOwner

$18.3K

291 sh · $63.00

Own +0%
SLGL Buy·P
Feb 2, 26

TenPercentOwner

$5.8K

100 sh · $58.00

Own +0%
SLGL Buy·P
Feb 2, 26

TenPercentOwner

$5.8K

100 sh · $58.00

Own +0%
SLGL Buy·P
Jan 27, 26

TenPercentOwner

$5.7K

100 sh · $57.05

Own +0%
SLGL Buy·P
Jan 23, 26

TenPercentOwner

$187.4K

3.3K sh · $56.37 avg · 2 lots

Own +1%
HROW Sell·S
Jan 6, 26

TenPercentOwner

$1.1M

20.0K sh · $53.35

Own -22%
SLGL Buy·P
Jan 5, 26

TenPercentOwner

$108.9K

2.6K sh · $42.00 avg · 2 lots

Own +1%
SLGL Buy·P
Dec 31, 25

TenPercentOwner

$2.8M

66.3K sh · $41.97 avg · 3 lots

Own +18%
SLGL Buy·P
Dec 26, 25

TenPercentOwner

$120.5K

2.9K sh · $41.49 avg · 3 lots

Own +1%
SLGL Buy·P
Dec 17, 25

TenPercentOwner

$110.4K

2.7K sh · $40.37

Own +1%
SLGL Buy·P
Dec 12, 25

TenPercentOwner

$3.5K

87 sh · $40.00

Own +0%
SLGL Buy·P
Dec 8, 25

TenPercentOwner

$29.5K

744 sh · $39.61 avg · 2 lots

Own +0%
SLGL Buy·P
Dec 3, 25

TenPercentOwner

$257.6K

6.9K sh · $37.53 avg · 2 lots

Own +2%
CDXS Sell·S
Dec 1, 25

TenPercentOwner

$878.3K

514.3K sh · $1.71 avg · 6 lots

Own -5%
CDXS Sell·S
Dec 1, 25

TenPercentOwner

$878.3K

514.3K sh · $1.71 avg · 6 lots

Own -74%
SLGL Buy·P
Nov 26, 25

TenPercentOwner

$37.9K

949 sh · $39.97 avg · 2 lots

Own +0%
SLGL Buy·P
Nov 20, 25

TenPercentOwner

$207.2K

5.8K sh · $35.83

Own +2%
CDXS Sell·S
Nov 12, 25

TenPercentOwner

$2.1M

1.1M sh · $1.94 avg · 3 lots

Own -9%
CDXS Sell·S
Nov 11, 25

TenPercentOwner

$1.9M

1.1M sh · $1.76 avg · 6 lots

Own -8%
CDXS Sell·S
Nov 11, 25

TenPercentOwner

$1.9M

1.1M sh · $1.76 avg · 6 lots

Own -83%
SNWV Buy·P
Oct 6, 25

TenPercentOwner

$38.4K

1.3K sh · $30.28

Own +0%
CDXS Buy·P
Aug 4, 25

TenPercentOwner

$227.9K

85.0K sh · $2.68 avg · 2 lots

Own +1%
CDXS Buy·P
Jul 30, 25

TenPercentOwner

$28.2K

10.0K sh · $2.82 avg · 2 lots

Own +0%
CDXS Buy·P
Jul 18, 25

TenPercentOwner

$282.0K

100.0K sh · $2.82

Own +1%
CDXS Buy·P
Jun 27, 25

TenPercentOwner

$239.0K

100.0K sh · $2.39

Own +1%

Date▾	Ticker	Role	Type	Shares	Own Δ	Price	Value
Jun 15, 2026	ACOG	10% Owner	Buy P	7.7K3 lots	+0%	$5.96 avg	$45.8K
Jun 10, 2026	ACOG	10% Owner	Buy P	30.7K2 lots	+1%	$5.98 avg	$183.7K
Jun 5, 2026	ACOG	10% Owner	Buy P	10.1K	+0%	$5.83	$58.6K
May 29, 2026	ACOG	10% Owner	Buy P	73.7K3 lots	+3%	$5.90 avg	$434.7K
May 21, 2026	ACOG	10% Owner	Buy P	24.4K2 lots	+1%	$5.77 avg	$140.5K
May 20, 2026	SLGL	10% Owner	Buy P	1.6K	+0%	$64.43	$100.7K
May 18, 2026	ACOG	10% Owner	Buy P	34.0K2 lots	+1%	$5.76 avg	$196.0K
May 13, 2026	SLGL	10% Owner	Buy P	3.4K2 lots	+1%	$67.36 avg	$231.5K
May 1, 2026	SNWV	10% Owner	Sell S	35.6K4 lots	-88%	$16.14 avg	$574.2K
Apr 29, 2026	SNWV	10% Owner	Sell S	70.6K4 lots	-92%	$18.05 avg	$1.3M
Apr 21, 2026	SNWV	10% Owner	Sell S	16.5K3 lots	-2%	$20.46 avg	$337.0K
Mar 30, 2026	ACOG	TenPercentOwner	Buy P	11.8K2 lots	+0%	$5.07 avg	$60.0K
Mar 26, 2026	ACOG	TenPercentOwner	Buy P	20.1K3 lots	+1%	$5.41 avg	$108.6K
Mar 24, 2026	SLGL	TenPercentOwner	Buy P	39.7K2 lots	New	$72.00 avg	$2.9M
Mar 19, 2026	ACOG	TenPercentOwner	Buy P	4.6K2 lots	+0%	$5.73 avg	$26.2K
Mar 16, 2026	ACOG	TenPercentOwner	Buy P	1.3K	+0%	$5.78	$7.7K
Mar 13, 2026	ACOG	TenPercentOwner	Buy P	13.1K2 lots	+1%	$5.79 avg	$75.7K
Mar 9, 2026	ACOG	TenPercentOwner	Buy P	4.1K2 lots	+0%	$5.83 avg	$23.8K
Mar 5, 2026	ACOG	TenPercentOwner	Buy P	66.8K3 lots	+3%	$5.80 avg	$387.7K
Mar 4, 2026	HROW	TenPercentOwner	Sell S	198.6K4 lots	-77%	$39.51 avg	$7.8M
Mar 3, 2026	ACOG	TenPercentOwner	Buy P	71.4K3 lots	+3%	$5.76 avg	$411.6K
Feb 27, 2026	ACOG	TenPercentOwner	Buy P	4.2K2 lots	+0%	$5.99 avg	$25.3K
Feb 27, 2026	HROW	TenPercentOwner	Sell S	5.0K	-7%	$54.18	$270.9K
Feb 24, 2026	ACOG	TenPercentOwner	Buy P	171.4K6 lots	New	$5.86 avg	$1.0M
Feb 13, 2026	SLGL	TenPercentOwner	Buy P	291	+0%	$63.00	$18.3K
Feb 2, 2026	SLGL	TenPercentOwner	Buy P	100	+0%	$58.00	$5.8K
Feb 2, 2026	SLGL	TenPercentOwner	Buy P	100	+0%	$58.00	$5.8K
Jan 27, 2026	SLGL	TenPercentOwner	Buy P	100	+0%	$57.05	$5.7K
Jan 23, 2026	SLGL	TenPercentOwner	Buy P	3.3K2 lots	+1%	$56.37 avg	$187.4K
Jan 6, 2026	HROW	TenPercentOwner	Sell S	20.0K	-22%	$53.35	$1.1M
Jan 5, 2026	SLGL	TenPercentOwner	Buy P	2.6K2 lots	+1%	$42.00 avg	$108.9K
Dec 31, 2025	SLGL	TenPercentOwner	Buy P	66.3K3 lots	+18%	$41.97 avg	$2.8M
Dec 26, 2025	SLGL	TenPercentOwner	Buy P	2.9K3 lots	+1%	$41.49 avg	$120.5K
Dec 17, 2025	SLGL	TenPercentOwner	Buy P	2.7K	+1%	$40.37	$110.4K
Dec 12, 2025	SLGL	TenPercentOwner	Buy P	87	+0%	$40.00	$3.5K
Dec 8, 2025	SLGL	TenPercentOwner	Buy P	7442 lots	+0%	$39.61 avg	$29.5K
Dec 3, 2025	SLGL	TenPercentOwner	Buy P	6.9K2 lots	+2%	$37.53 avg	$257.6K
Dec 1, 2025	CDXS	TenPercentOwner	Sell S	514.3K6 lots	-5%	$1.71 avg	$878.3K
Dec 1, 2025	CDXS	TenPercentOwner	Sell S	514.3K6 lots	-74%	$1.71 avg	$878.3K
Nov 26, 2025	SLGL	TenPercentOwner	Buy P	9492 lots	+0%	$39.97 avg	$37.9K
Nov 20, 2025	SLGL	TenPercentOwner	Buy P	5.8K	+2%	$35.83	$207.2K
Nov 12, 2025	CDXS	TenPercentOwner	Sell S	1.1M3 lots	-9%	$1.94 avg	$2.1M
Nov 11, 2025	CDXS	TenPercentOwner	Sell S	1.1M6 lots	-8%	$1.76 avg	$1.9M
Nov 11, 2025	CDXS	TenPercentOwner	Sell S	1.1M6 lots	-83%	$1.76 avg	$1.9M
Oct 6, 2025	SNWV	TenPercentOwner	Buy P	1.3K	+0%	$30.28	$38.4K
Aug 4, 2025	CDXS	TenPercentOwner	Buy P	85.0K2 lots	+1%	$2.68 avg	$227.9K
Jul 30, 2025	CDXS	TenPercentOwner	Buy P	10.0K2 lots	+0%	$2.82 avg	$28.2K
Jul 18, 2025	CDXS	TenPercentOwner	Buy P	100.0K	+1%	$2.82	$282.0K
Jun 27, 2025	CDXS	TenPercentOwner	Buy P	100.0K	+1%	$2.39	$239.0K

Buy Sell Non-market (grant · exercise · gift)

About Opaleye Management Inc.

This profile aggregates every SEC Form 4 insider transaction reported by Opaleye Management Inc. across all companies they trade. Open-market purchases (code P) and sales (code S) are the highest-signal, discretionary trades; grants (A), option exercises (M) and gifts (G) reflect compensation rather than conviction and carry no market price. Figures cover the selected period and update as new filings are ingested.