TYRA

insider transactions

Tyra Biosciences, Inc. — buys & sells by directors, officers and 10% owners (SEC Form 4).

30D 90D 1Y

Net shares · 30d

+20.1M

21.2M buy · 1.1M sell

Net value · 30d

$423.3M

$423.8M in · $427.3K out

Sentiment · 30d

Net buying

100% buying · 0% selling

Open-market trades · 30d

21.2M buy · 1.1M sell

Net buy / sell volume

Tap or hover the chart for daily net volume. Green = net buying, red = net selling.

All transactions

Grant·A
Jun 17, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

17.3K sh

Own New
Sell·S
Jun 16, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$3.7K

9.9K sh · $0.37

Own -3%
Sell·S
Jun 16, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$51.7K

139.7K sh · $0.37

Own -3%
Grant·A
Jun 15, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund II, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

22.1K sh

Own New
Sell·S
Jun 15, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$3.3K

8.6K sh · $0.39

Own -2%
Sell·S
Jun 15, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$46.9K

120.2K sh · $0.39

Own -2%
Sell·S
Jun 12, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$4.5K

11.3K sh · $0.40

Own -3%
Sell·S
Jun 12, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$63.6K

159.1K sh · $0.40

Own -3%
Sell·S
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$6.6K

17.4K sh · $0.38

Own -5%
Sell·S
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$93.1K

245.1K sh · $0.38

Own -5%
Grant·A
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

57.2K sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

1.7M sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

9.4M sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

160.6K sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

642.2K sh

Own New
Buy·P
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$29.2M

1.5M sh · $20.00

Own +123%
Buy·P
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$394.6M

19.7M sh · $20.00

Own +301%
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

1.2M sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

6.6M sh

Own New
Sell·S
Jun 10, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$1.1K

3.1K sh · $0.37

Own -1%
Sell·S
Jun 10, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$15.9K

42.9K sh · $0.37

Own -1%
Grant·A
Jun 10, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

37.0K sh

Own New
Sell·S
Jun 9, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$9.1K

24.6K sh · $0.37

Own -6%
Sell·S
Jun 9, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$127.7K

345.2K sh · $0.37

Own -6%
Grant·A
Jun 9, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director

$0

20.2K sh

Own New
Grant·A
May 28, 26

Rehan Verjee

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

Jake Simson

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

Stephen Michael Rothenberg

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

Susan Moran

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

Robert J More

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

13.2K sh

Own New
Grant·A
May 28, 26

Adele M. Gulfo

Director

$0

13.2K sh

Own New
Grant·A
May 27, 26

Robert J More

Director

$0

16.0K sh

Own New
Grant·A
May 27, 26

Robert J More

Director

$0

8.0K sh

Own +20%

Date▾	Insider	Role	Type	Shares	Own Δ	Price	Value
Jun 17, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	17.3K	New	—	$0
Jun 16, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	9.9K	-3%	$0.37	$3.7K
Jun 16, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	139.7K	-3%	$0.37	$51.7K
Jun 15, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund II, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	22.1K	New	—	$0
Jun 15, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	8.6K	-2%	$0.39	$3.3K
Jun 15, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	120.2K	-2%	$0.39	$46.9K
Jun 12, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	11.3K	-3%	$0.40	$4.5K
Jun 12, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	159.1K	-3%	$0.40	$63.6K
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	17.4K	-5%	$0.38	$6.6K
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	245.1K	-5%	$0.38	$93.1K
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	57.2K	New	—	$0
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	1.7M	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	9.4M	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	160.6K	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	642.2K	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Buy P	1.5M	+123%	$20.00	$29.2M
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Buy P	19.7M	+301%	$20.00	$394.6M
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	1.2M	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	6.6M	New	—	—
Jun 10, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	3.1K	-1%	$0.37	$1.1K
Jun 10, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	42.9K	-1%	$0.37	$15.9K
Jun 10, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	37.0K	New	—	$0
Jun 9, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	24.6K	-6%	$0.37	$9.1K
Jun 9, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	345.2K	-6%	$0.37	$127.7K
Jun 9, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director	Grant A	20.2K	New	—	$0
May 28, 2026	Rehan Verjee	Director	Grant A	13.2K	New	—	$0
May 28, 2026	Jake Simson	Director	Grant A	13.2K	New	—	$0
May 28, 2026	Stephen Michael Rothenberg	Director	Grant A	13.2K	New	—	$0
May 28, 2026	Susan Moran	Director	Grant A	13.2K	New	—	$0
May 28, 2026	Robert J More	Director	Grant A	13.2K	New	—	$0
May 28, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	13.2K	New	—	$0
May 28, 2026	Adele M. Gulfo	Director	Grant A	13.2K	New	—	$0
May 27, 2026	Robert J More	Director	Grant A	16.0K	New	—	$0
May 27, 2026	Robert J More	Director	Grant A	8.0K	+20%	—	$0

About TYRA insider trading

This page tracks insider transactions for Tyra Biosciences, Inc. (TYRA) reported to the U.S. Securities and Exchange Commission on Form 4. Corporate insiders — directors, executive officers and beneficial owners of more than 10% of the stock — must disclose their trades within two business days. Open-market purchases (code P) and sales (code S) made at the insider's discretion are the most-watched opportunistic signals, while awards (A), option exercises (M) and tax-withholding (F) reflect compensation rather than conviction. Trades marked 10b5-1 were made under a pre-arranged plan and are considered routine. A cluster buy — several insiders buying within a short window — is historically a stronger bullish indicator than any single trade.