TYRA

insider transactions

Tyra Biosciences, Inc. — buys & sells by directors, officers and 10% owners (SEC Form 4).

30D 90D 1Y

Cluster buy signal: 2 different insiders made open-market purchases in the last 90 days, totalling $487.2M.

Net shares · 90d

+25.6M

30.3M buy · 4.7M sell

Net value · 90d

$436.4M

$487.2M in · $50.8M out

Sentiment · 90d

Net buying

91% buying · 9% selling

Open-market trades · 90d

30.3M buy · 4.7M sell

Net buy / sell volume

Tap or hover the chart for daily net volume. Green = net buying, red = net selling.

All transactions

Grant·A
Jun 17, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

17.3K sh

Own New
Sell·S
Jun 16, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$3.7K

9.9K sh · $0.37

Own -3%
Sell·S
Jun 16, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$51.7K

139.7K sh · $0.37

Own -3%
Grant·A
Jun 15, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund II, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

22.1K sh

Own New
Sell·S
Jun 15, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$3.3K

8.6K sh · $0.39

Own -2%
Sell·S
Jun 15, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$46.9K

120.2K sh · $0.39

Own -2%
Sell·S
Jun 12, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$4.5K

11.3K sh · $0.40

Own -3%
Sell·S
Jun 12, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$63.6K

159.1K sh · $0.40

Own -3%
Sell·S
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$6.6K

17.4K sh · $0.38

Own -5%
Sell·S
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$93.1K

245.1K sh · $0.38

Own -5%
Grant·A
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

57.2K sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

1.7M sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

9.4M sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

160.6K sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

642.2K sh

Own New
Buy·P
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$29.2M

1.5M sh · $20.00

Own +123%
Buy·P
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$394.6M

19.7M sh · $20.00

Own +301%
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

1.2M sh

Own New
Exercise·C
Jun 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

—

6.6M sh

Own New
Sell·S
Jun 10, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$1.1K

3.1K sh · $0.37

Own -1%
Sell·S
Jun 10, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$15.9K

42.9K sh · $0.37

Own -1%
Grant·A
Jun 10, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

37.0K sh

Own New
Sell·S
Jun 9, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$9.1K

24.6K sh · $0.37

Own -6%
Sell·S
Jun 9, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$127.7K

345.2K sh · $0.37

Own -6%
Grant·A
Jun 9, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director

$0

20.2K sh

Own New
Grant·A
May 28, 26

Rehan Verjee

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

Jake Simson

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

Stephen Michael Rothenberg

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

Susan Moran

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

Robert J More

Director

$0

13.2K sh

Own New
Grant·A
May 28, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$0

13.2K sh

Own New
Grant·A
May 28, 26

Adele M. Gulfo

Director

$0

13.2K sh

Own New
Grant·A
May 27, 26

Robert J More

Director

$0

16.0K sh

Own New
Grant·A
May 27, 26

Robert J More

Director

$0

8.0K sh

Own +20%
Sell·S
May 12, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$4.3K

6.7K sh · $0.64

Own -2%
Sell·S
May 12, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$60.4K

94.4K sh · $0.64

Own -2%
Sell·S
May 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$3.9K

5.8K sh · $0.67

Own -1%
Sell·S
May 11, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$54.7K

81.7K sh · $0.67

Own -1%
Sell·S
May 8, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$17.8K

25.0K sh · $0.71

Own -6%
Sell·S
May 8, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

$249.6K

351.5K sh · $0.71

Own -6%
Grant·A
May 5, 26

Douglas J Warner

Chief Medical Officer

$0

85.0K sh

Own New
Grant·A
May 5, 26

Douglas J Warner

Chief Medical Officer

$0

25.0K sh

Own New
Grant·A
May 5, 26

Yuliya Rueb KEY

Vice President, Finance (PAO)

$0

28.0K sh

Own New
Grant·A
May 5, 26

Yuliya Rueb KEY

Vice President, Finance (PAO)

$0

8.3K sh

Own +24%
Grant·A
May 5, 26

Todd Harris KEY

President and CEO

$0

265.0K sh

Own New
Grant·A
May 5, 26

Todd Harris KEY

President and CEO

$0

79.0K sh

Own +6%
Grant·A
May 5, 26

Alan Fuhrman KEY

Chief Financial Officer

$0

67.0K sh

Own New
Grant·A
May 5, 26

Alan Fuhrman KEY

Chief Financial Officer

$0

20.0K sh

Own +124%
Grant·A
May 5, 26

Bhavesh Ashar

Chief Operating Officer

$0

50.3K sh

Own New
Grant·A
May 5, 26

Bhavesh Ashar

Chief Operating Officer

$0

15.0K sh

Own New
Other·J
Apr 27, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

—

1.4M sh
Other·J
Apr 27, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

10% Owner

—

1.4M sh
Sell·S
Apr 22, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$2.6M

165.2K sh · $15.77

Own -6%
Sell·S
Apr 20, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$2.7M

172.0K sh · $15.77

Own -6%
Sell·S
Apr 17, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$7.5M

458.4K sh · $16.28

Own -14%
Sell·S
Apr 15, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$858.8K

53.6K sh · $16.01

Own -2%
Sell·S
Apr 14, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$2.5M

153.7K sh · $15.97

Own -5%
Sell·S
Apr 13, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$8.6M

530.6K sh · $16.15

Own -13%
Sell·S
Apr 10, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$13.0K

828 sh · $15.75

Own -0%
Sell·S
Apr 9, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$2.2M

135.2K sh · $16.59

Own -3%
Sell·S
Apr 8, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$2.2M

130.9K sh · $16.91

Own -3%
Sell·S
Apr 8, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$5.8M

353.2K sh · $16.32

Own -8%
Sell·S
Apr 6, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$125.3K

6.8K sh · $18.50

Own -0%
Sell·S
Apr 6, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$774.2K

44.7K sh · $17.31

Own -1%
Sell·S
Apr 6, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$8.9M

537.8K sh · $16.51

Own -10%
Sell·S
Apr 2, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$29.1K

1.5K sh · $19.06

Own -0%
Sell·S
Apr 2, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$4.7M

258.5K sh · $18.23

Own -5%
Buy·P
Mar 30, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$6.3M

971.1K sh · $6.50

Own +4%
Buy·P
Mar 30, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director

$1.4M

58.3K sh · $24.16

Own +1%
Buy·P
Mar 27, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$16.0M

2.5M sh · $6.43

Own +11%
Buy·P
Mar 27, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah

Director

$7.4M

310.7K sh · $23.67

Own +6%
Exercise·M
Mar 26, 26

Gilla Kaplan

Director

$0

53.2K sh

Own New
Other·D
Mar 26, 26

Gilla Kaplan

Director

$2.0M

53.2K sh · $37.75

Own -65%
Exercise·M
Mar 26, 26

Gilla Kaplan

Director

$119.6K

53.2K sh · $2.25

Own +188%
Buy·P
Mar 26, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$2.2M

351.2K sh · $6.38

Own +2%
Buy·P
Mar 26, 26

RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah

Director, 10% Owner

$30.0M

5.0M sh · $6.06

Own +27%
Exercise·M
Mar 25, 26

Gilla Kaplan

Director

$0

14.3K sh

Own +37%
Sell·S
Mar 25, 26

Gilla Kaplan

Director

$528.5K

14.3K sh · $36.97

Own -34%
Exercise·M
Mar 25, 26

Gilla Kaplan

Director

$32.2K

14.3K sh · $2.25

Own +51%

Date▾	Insider	Role	Type	Shares	Own Δ	Price	Value
Jun 17, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	17.3K	New	—	$0
Jun 16, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	9.9K	-3%	$0.37	$3.7K
Jun 16, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	139.7K	-3%	$0.37	$51.7K
Jun 15, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund II, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	22.1K	New	—	$0
Jun 15, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	8.6K	-2%	$0.39	$3.3K
Jun 15, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	120.2K	-2%	$0.39	$46.9K
Jun 12, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	11.3K	-3%	$0.40	$4.5K
Jun 12, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	159.1K	-3%	$0.40	$63.6K
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	17.4K	-5%	$0.38	$6.6K
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	245.1K	-5%	$0.38	$93.1K
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	57.2K	New	—	$0
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	1.7M	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	9.4M	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	160.6K	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	642.2K	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Buy P	1.5M	+123%	$20.00	$29.2M
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Buy P	19.7M	+301%	$20.00	$394.6M
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	1.2M	New	—	—
Jun 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Exercise C	6.6M	New	—	—
Jun 10, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	3.1K	-1%	$0.37	$1.1K
Jun 10, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	42.9K	-1%	$0.37	$15.9K
Jun 10, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	37.0K	New	—	$0
Jun 9, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	24.6K	-6%	$0.37	$9.1K
Jun 9, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	345.2K	-6%	$0.37	$127.7K
Jun 9, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director	Grant A	20.2K	New	—	$0
May 28, 2026	Rehan Verjee	Director	Grant A	13.2K	New	—	$0
May 28, 2026	Jake Simson	Director	Grant A	13.2K	New	—	$0
May 28, 2026	Stephen Michael Rothenberg	Director	Grant A	13.2K	New	—	$0
May 28, 2026	Susan Moran	Director	Grant A	13.2K	New	—	$0
May 28, 2026	Robert J More	Director	Grant A	13.2K	New	—	$0
May 28, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Grant A	13.2K	New	—	$0
May 28, 2026	Adele M. Gulfo	Director	Grant A	13.2K	New	—	$0
May 27, 2026	Robert J More	Director	Grant A	16.0K	New	—	$0
May 27, 2026	Robert J More	Director	Grant A	8.0K	+20%	—	$0
May 12, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	6.7K	-2%	$0.64	$4.3K
May 12, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	94.4K	-2%	$0.64	$60.4K
May 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	5.8K	-1%	$0.67	$3.9K
May 11, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	81.7K	-1%	$0.67	$54.7K
May 8, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	25.0K	-6%	$0.71	$17.8K
May 8, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Sell S	351.5K	-6%	$0.71	$249.6K
May 5, 2026	Douglas J Warner	Chief Medical Officer	Grant A	85.0K	New	—	$0
May 5, 2026	Douglas J Warner	Chief Medical Officer	Grant A	25.0K	New	—	$0
May 5, 2026	Yuliya Rueb KEY	Vice President, Finance (PAO)	Grant A	28.0K	New	—	$0
May 5, 2026	Yuliya Rueb KEY	Vice President, Finance (PAO)	Grant A	8.3K	+24%	—	$0
May 5, 2026	Todd Harris KEY	President and CEO	Grant A	265.0K	New	—	$0
May 5, 2026	Todd Harris KEY	President and CEO	Grant A	79.0K	+6%	—	$0
May 5, 2026	Alan Fuhrman KEY	Chief Financial Officer	Grant A	67.0K	New	—	$0
May 5, 2026	Alan Fuhrman KEY	Chief Financial Officer	Grant A	20.0K	+124%	—	$0
May 5, 2026	Bhavesh Ashar	Chief Operating Officer	Grant A	50.3K	New	—	$0
May 5, 2026	Bhavesh Ashar	Chief Operating Officer	Grant A	15.0K	New	—	$0
Apr 27, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Other J	1.4M	—	—	—
Apr 27, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	10% Owner	Other J	1.4M	—	—	—
Apr 22, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	165.2K	-6%	$15.77	$2.6M
Apr 20, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	172.0K	-6%	$15.77	$2.7M
Apr 17, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	458.4K	-14%	$16.28	$7.5M
Apr 15, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	53.6K	-2%	$16.01	$858.8K
Apr 14, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	153.7K	-5%	$15.97	$2.5M
Apr 13, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	530.6K	-13%	$16.15	$8.6M
Apr 10, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	828	-0%	$15.75	$13.0K
Apr 9, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	135.2K	-3%	$16.59	$2.2M
Apr 8, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	130.9K	-3%	$16.91	$2.2M
Apr 8, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	353.2K	-8%	$16.32	$5.8M
Apr 6, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	6.8K	-0%	$18.50	$125.3K
Apr 6, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	44.7K	-1%	$17.31	$774.2K
Apr 6, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	537.8K	-10%	$16.51	$8.9M
Apr 2, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	1.5K	-0%	$19.06	$29.1K
Apr 2, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Sell S	258.5K	-5%	$18.23	$4.7M
Mar 30, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Buy P	971.1K	+4%	$6.50	$6.3M
Mar 30, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director	Buy P	58.3K	+1%	$24.16	$1.4M
Mar 27, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Buy P	2.5M	+11%	$6.43	$16.0M
Mar 27, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / RA Capital Nexus Fund III, L.P. / Peter Kolchinsky / Rajeev M. Shah	Director	Buy P	310.7K	+6%	$23.67	$7.4M
Mar 26, 2026	Gilla Kaplan	Director	Exercise M	53.2K	New	—	$0
Mar 26, 2026	Gilla Kaplan	Director	Other D	53.2K	-65%	$37.75	$2.0M
Mar 26, 2026	Gilla Kaplan	Director	Exercise M	53.2K	+188%	$2.25	$119.6K
Mar 26, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Buy P	351.2K	+2%	$6.38	$2.2M
Mar 26, 2026	RA CAPITAL MANAGEMENT, L.P. / RA Capital Healthcare Fund LP / Peter Kolchinsky / Rajeev M. Shah	Director, 10% Owner	Buy P	5.0M	+27%	$6.06	$30.0M
Mar 25, 2026	Gilla Kaplan	Director	Exercise M	14.3K	+37%	—	$0
Mar 25, 2026	Gilla Kaplan	Director	Sell S	14.3K	-34%	$36.97	$528.5K
Mar 25, 2026	Gilla Kaplan	Director	Exercise M	14.3K	+51%	$2.25	$32.2K

About TYRA insider trading

This page tracks insider transactions for Tyra Biosciences, Inc. (TYRA) reported to the U.S. Securities and Exchange Commission on Form 4. Corporate insiders — directors, executive officers and beneficial owners of more than 10% of the stock — must disclose their trades within two business days. Open-market purchases (code P) and sales (code S) made at the insider's discretion are the most-watched opportunistic signals, while awards (A), option exercises (M) and tax-withholding (F) reflect compensation rather than conviction. Trades marked 10b5-1 were made under a pre-arranged plan and are considered routine. A cluster buy — several insiders buying within a short window — is historically a stronger bullish indicator than any single trade.